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Hidden Link Between Artificial Sweeteners and Chronic Pain

October 28, 2025

If you're living with chronic back or neck pain, you've probably tested everything—stretches, heating pads, over-the-counter medications. But have you thought about the impact your diet drinks and “sugar-free” snacks may have? Developing research intimates that artificial sweeteners might be sabotaging your pain relief efforts through an unexpected pathway: your gut. Medical Spine and Sports Injury and Rehab Centers is here to explore any potential avenues to help you get back to enjoying your life!

THE GUT-PAIN CONNECTION

Your gut does more than digest food—it houses trillions of bacteria that bear on inflammation in your spine, neck, back, and throughout your body. New research has pointed to a direct connection between artificial sweeteners, gut health, and how sensitive you are to chronic pain.

A 2025 Mendelian randomization study by Zhao and colleagues demonstrated that artificially sweetened foods can actually cause chronic pain by disrupting the gut microbiota. (1) This isn't just correlation—the research shows a causal relationship between using these sweeteners and higher pain levels.

HOW SWEETNERS TRIGGER PAIN

Artificial sweeteners can change the balance of beneficial bacteria living in your digestive system. These disturbed microbes trigger inflammatory responses that travel throughout your body. As documented in a comprehensive 2019 review by Guo and colleagues in the British Journal of Anaesthesia, the gut microbiota directly regulates pain through multiple molecular mechanisms, including immune system activation and nerve sensitivity. (2)

For back and neck pain sufferers seeking help at Medical Spine and Sports Injury and Rehab Centers, this inflammation can raise pain sensitivity in already weak areas. Your spinal nerves become more reactive, making existing discomfort worse and potentially slowing your recovery.

TAKING ACTION

Before your next chiropractic appointment, you might want to explore whether artificial sweeteners are affecting your pain levels. Consider trying a two-week experiment where you reduce or swap out products containing artificial sweeteners. This could involve choosing water or herbal tea instead of diet sodas, or opting for snacks without ingredients like aspartame, sucralose, and saccharin.

Chiropractic physicians recognize that pain management demands a whole-body approach. While spinal adjustments tackle mechanical dysfunction, lowering inflammation through dietary modifications can significantly enhance treatment outcomes. By sustaining your gut health, you're making an internal environment more advantageous to healing and less responsive to pain signals. Little dietary changes might be a valuable extra to your pain relief strategy with Medical Spine and Sports Injury and Rehab Centers.

Your path to back pain relief and/or neck pain relief may start with what you don’t put into your grocery cart.

CONTACT Medical Spine and Sports Injury and Rehab Centers

Listen to this PODCAST with Dr. James Cox, on The Back Doctors Podcast with Dr. Michael Johnson as he illustrates the impact inflammation has on the immune system and the benefit of chiropractic care like The Cox® Technic System of Spinal Pain Management that Baton Rouge chiropractic patients may experience.

Make your Baton Rouge chiropractic appointment soon.